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Tesamorelin
Tesamorelin Epidermal Growth Factor For Hiv Lipodystrophy Treatment

Tesamorelin Epidermal Growth Factor For Hiv Lipodystrophy Treatment

Tesamorelin, (formerly known as TH9507), is a type of peptide called a growth hormone-releasing factor (GHRP). GHRP causes growth hormone to be created and spread in the body, which helps increase metabolism, reduce belly fat, improve body shape, and use of energy. Tesamorelin (formerly known as TH9507) is a synthetic growth hormone-releasing factor that stimulates the pituitary gland in the brain to secrete growth hormone; this indirect approach appears to maintain more stable, natural levels, like CJC-1295 DAC,.

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Tesamorelin, (formerly known as TH9507), is a type of peptide called a growth hormone-releasing factor (GHRP). GHRP causes growth hormone to be created and spread in the body, which helps increase metabolism, reduce belly fat, improve body shape, and use of energy. Tesamorelin (formerly known as TH9507) is a synthetic growth hormone-releasing factor that stimulates the pituitary gland in the brain to secrete growth hormone; this indirect approach appears to maintain more stable, natural levels, like CJC-1295 DAC,.

 

Clinical trials have shown that tesamorelin significantly reduces abdominal fat with fewer side effects than human growth hormone itself, although abdominal fat may return after the Tesamorlein is discontinued (depending upon the individual). Tesamorelin has been shown to reduce lipodystrophy in HIV-infected individuals as well as similarly reducing abdominal fat in NON-HIV-Infected individuals.

 


 

Tesamorelin Peptide

 tesamorelin


Product Name: Tesamorelin
Molecular Formula: C221H366N72O67S
Molecular Weight: 5135.77794
PubChem: CID 44201342
Synonyms:Hex-hGRF, ThGRF(1-44), TH-9507, (Hexenoyl trans-3)-hGRF(1-44)-NH2

Sequence (Three-Letter Code): trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

 

 

 

 

 


Tesamorelin Boosts Cognition in Elderly

 

Tesamorelin is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date, clinical studies suggest that Tesamorelin reduces visceral fat in HIV-infected patients with abdominal lipo-hypertrophy as well as reducing abdominal fat in all individuals studied.
A peptide that increases growth hormone release improved several measures of cognitive function in cognitively normal and mildly impaired older individuals in a placebo-controlled trial, a researcher said here. Scores on standard tests of executive function and verbal memory were significantly higher in participants given tesamorelin (Egrifta), a synthetic analog of growth hormone releasing hormone (GHRH), in a 20-week trial, according to Laura D. Baker, PhD.. Participants taking the drug in the 78-person trial also reported greater subjective improvement in cognition relative to the placebo group.
In animal studies, GHRH administration improved biomarkers of brain function as well as performance on cognition tests. And a 2006 clinical trial with GHRH found small but significant improvements in cognitive test scores in healthy older adults. In the current study, funded by the National Institute on Aging, 41 cognitively normal adults and 37 with mild cognitive impairment were randomized to placebo or tesamorelin at 1 mg/day subcutaneously.
Mean participant age was 66 to 70 among the four groups. Scores on the Mini-Mental State Examination averaged 29 for the normal participants and 28 for those with mild impairments. Normal and impaired participants differed more at baseline on a test of story recall, with mean scores of 54 and 44, respectively. Tesamorelin appeared to have a protective effect relative to placebo among the cognitively impaired patients on this measure. At the final evaluation, scores declined an average of five points with placebo, whereas those assigned to tesamorelin had a mean decline of less than one point .


 

Fat Loss and the Tesamorelin Peptide

 

Tesamorelin has been shown to reduce lipodystrophy in HIV-infected individuals. Lipodystrophy is a condition that causes changes in placement of body fat, including wasting and fat accumulation, and changes in metabolism. Similar to Tesamorelin is Sermorelin, which may be taken with GHRP-6 is clinical trials, that also promotes HGH production and possible fat loss. Individuals with lipodystrophy may develop excess fat most notably around the liver, stomach, and other abdominal organs

 

 

Why Are Bodybuilders So Interested in Tesamorelin?
Tesamorelin is a peptide which is renowned for its ability to reduce belly fat in patients who have the HIV virus. However, it’s also a peptide that bodybuilders who are not HIV-positive are becoming very curious about…

 

Due to its ability to reduce fatty deposits in the midsection, it actually offers potential benefits to many different types of people. To help you get educated, let’s talk about the basics – what this peptide is, how it works, which side effects it may cause, how it is injected and how to get it. Once we’ve shared this information, you’ll have a deeper understanding of Tesamorelin.


Discover Basic Tesamorelin Facts
Tesamorelin is marketed under the brand name, Egrifta and it’s an injectable peptide which is currently available by prescription only. It functions well for deep belly fat reduction purposes due to its action upon pituitary cells which are located within the brain.
This action sparks greater production of HGH (Human Growth Hormone). It is classified as a Growth Hormone-releasing Factor peptide. HGH is a powerful substance which we make naturally in our bodies. As we age, our HGH levels decline. By our 20s, we are already making less HGH.
At the moment, this drug is FDA-approved solely for treatment of belly fat in patients with HIV. There are some who believe that Tesamorelin also has the power to improve the cardiovascular health of HIV sufferers. However, others do believe differently, so this is still under debate. More clinical studies will be needed before secondary benefits of this peptide are definitively proven (or excluded).
According to one clinical study, 10.9 percent of patients who were given Tesamorelin experienced reductions in deep belly fat. These patients suffered from HIV. Reductions in trunk fat, waist size and waist-to-hip ratios were recorded during the study. However, limbs and abdominal SC fat levels remained the same.
During treatment, insulin-like growth factor 1 was boosted. However, glucose parameters were not altered. This drug didn’t trigger negative side effects in most patients. However, results were temporary, as patients who were switched to a placebo lost their improvements. The study lasted six months in total. Overall, visceral fat levels decreased by eighteen percent. By reducing deep belly fat with this peptide, bodybuilders may reveal the muscle underneath.


How Does Tesamorelin Work?
Those who are infected with the HIV virus must sometimes deal with a health issue which is known as lipodystrophy. This is a syndrome which is triggered by different causes. Certain people with this health issue (one in four of HIV patients), experience fat loss – however, others experience weight gain in key areas, including the throat, the chest (or breasts) and the tummy. In addition to this weight gain, increased blood fat levels and differences in insulin levels may be present.
Weight gain in the abdomen is characterized by visceral fat gain. This type of “deep belly fat” is found under the muscles of the stomach, close to internal organs, so it pushes up the risk for coronary disease. In addition, people who pack on deep belly fat due to being HIV positive may suffer from low self-esteem due to body issues.

 

Tesamorelin helps to banish deep belly fat and may raise self-esteem. Since it works so well for people with HIV, bodybuilders wonder if it might help them to lose visceral belly fat as well!
Currently, this peptide is being utilized on non-HIV patients, in new tests. So, bodybuilders shouldn’t have to wait much longer in order to find out if it’s appropriate for their needs.
Side Effects of Tesamorelin
Like most peptides, this peptide does trigger side effects in some users. Since research regarding effects on HIV-negative users isn’t available (it likely will be in the foreseeable future), this side effect information is based on reports from patients who are HIV-positive. Side effects related to usage of Tesamorelin include depression, trouble sleeping, sweating at night, rashes and itchiness (usually not too severe), sick stomach and skin irritation/discomfort around the injection site.
As well, patients who take the brand name version of this peptide, which is known as Egrifta, may experience swollen hands, ankles and/or feet. Some patients also suffer from pain and/or stiffness within muscle tissue and joint tissue. Wrist pain is another possible side effect of treatment with Tesamorelin, as is hand/finger numbness and rapid heartbeat. A fluttering sensation in the chest may also happen during therapy with this formula.
Those who’ve had tumors or suffer from diabetes should talk to their doctors before starting treatment with this peptide. As well, pregnant women shouldn’t use the peptide, as it may damage the health of fetuses. It’s also important to discuss any allergies or current medications with a doctor before he or she may decide if this peptide is right for your needs. Contraindications may occur, even when a patient is taking over the counter meds or herbal remedies.
How to Use the Peptide
First off, you’ll need a prescription in order to access this peptide. It may be difficult to get a prescription if you’re not HIV-positive, at least at the moment. In the future, this prescription-grade peptide may become much simpler to access. At present, many peptides are available without prescriptions, although some of them still require a doctor’s prescription.
This peptide is an injectable. It comes in a dried format and it’s meant to be reconstituted with sterile water before being injected. Full instructions should be included with each vial of Tesamorelin.
To reconstitute this lyophilized powder, add 2.1 milliliters of diluent and then combine both ingredients by carefully rolling the tube within your hands for half a minute. Don’t shake the mixture before you use it. Being too aggressive while mixing it may damage its efficacy and this is why it must be handled gently at all times.
To store unused portions of this peptide, keep it in a fridge which features a temperature between 2-8 Celcius. Don’t store it past the expiration date. Also, keep it away from light and don’t let it freeze. Also, store diluents according to package directions.

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