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Norditropin pen
Norditropin 30IU pen growth hormone

Norditropin 30IU pen growth hormone

Сontains liquid growth hormone (GH) in a pre-filled multi-dose disposable syringe pen for multiple injections.
The active substance Norditropin NordiLet-is somatropin, identical to the 191 amino acid sequence of human pituitary growth hormone (GH). Norditropin is produced using recombinant technology and is supplied as a transparent stable sterile solution.

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Сontains liquid growth hormone (GH) in a pre-filled multi-dose disposable syringe pen for multiple injections.
The active substance Norditropin NordiLet-is somatropin, identical to the 191 amino acid sequence of human pituitary growth hormone (GH). Norditropin is produced using recombinant technology and is supplied as a transparent stable sterile solution.

PHARMACODYNAMICS

In adults with growth hormone deficiency, somatropin reduces fat mass, increases muscle mass, and also strength, energy and subjective well-being. Treatment of patients with GH deficiency with somatropin normalizes serum level of IGF-1. The primary and secondary pharmacological effects of somatropin are identical to those of the pituitary GR.

In addition, the following effects have been demonstrated for somatropin:

Tissue growth

Stimulation of skeletal muscle growth in patients with GDR, as well as an increase in the number and size of muscle cells

Protein metabolism

The delay in nitrogen is manifested by a decreased excretion of nitrogen in the urine and a reduced content of urea nitrogen in the serum

Fat metabolism

In patients, the administration of somatropin leads to the mobilization of lipids, a reduction in body fat reserves and an increase in fatty acids in the plasma

Mineral exchange

Somatropin induces retention of sodium, potassium and phosphorus in the body.

 

After therapy with somatropin, the concentrations of inorganic phosphates in serum increase in patients. Somatropin does not significantly affect the level of serum calcium.

Somatropin, replenishing the deficiency of endogenous growth hormone, contributes to the normalization of body structure by increasing muscle mass and reducing body fat.

Most effects of somatropin are realized through insulin-like growth factor I (IGF-I), which is produced in all cells of the body (mainly by liver cells). More than 90% of IGF-I is associated with proteins (GHBP), of which the most important is IRFSB-3.

Somatropin enhances the restructuring of bone tissue, which is manifested by an increase in the activity of biochemical bone markers in plasma. In adults, during the first months of treatment, due to more pronounced bone resorption, a decrease in its mass is observed, however, with continued treatment, the mass of bone tissue increases.

PHARMACOKINETICS

Approximately 80% of somatropin is absorbed after subcutaneous injection, with maximum serum concentrations reaching 3-4 hours.

DOSING AND ADMINISTRATION

Norditropin NordiLet is a solution for subcutaneous injection, located in cartridges in a multi-dose, disposable, pre-filled syringe pen, for multiple injections intended for use with NovoFine needles.

The dosage is set by clicking. Norditropin NordiLet allows you to do from 1 to 29 clicks of the dose setting for each injection, which is also by a click. The dose of the drug for each click is 0.1333 mg (0.4 IU); The package contains an instruction containing a table of dose transfer (mg) in the appropriate number of clicks.

The dose of the drug is prescribed individually. It is usually recommended to do one subcutaneous injection at night. To prevent the development of lipoatrophy, injection sites should be changed. The procedure for the injection is set out in the instructions for Norditropin NordiLet. Patients should be reminded of the need to wash their hands with soap and / or a disinfectant before using Norditropin NordiLet. Never shake Norditropin NordiLet violently.

DOSING HGH

Substitution therapy. It is recommended to begin treatment with the use of low doses of the drug: 0.15-0.3 mg / day (which corresponds to 0.45-0.9 IU / day) and gradually increase the dose every month until the dose that is required by a particular patient is achieved.

As a control parameter for titrating the dose, serum level of IGF-I can be used. As the patient’s age increases, the need for growth hormone decreases.

The maintenance dose of the drug is selected individually, but rarely exceeds 1 mg / day (corresponding to 3 IU / day).

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Subject : Norditropin 30IU pen growth hormone

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