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MGF
MGF Mechano Growth Factor

MGF Mechano Growth Factor

Mechano Growth Factor, better known as MGF, is a splice variant of Insulin-Like Growth Factor-1 (IGF-1). This hormone is largely responsible for the healing and building of damaged muscle tissue post exercise or any other activity that causes damage to the muscle tissue. Although somewhat simplistic to say, the best way to view MGF is as a byproduct of IGF-1, specifically, IGF-1Ec, which represents the predominant splice in the two splice system created by IGF-1.

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MGF (Mechano Growth Factor)


Mechano Growth Factor, better known as MGF, is a splice variant of Insulin-Like Growth Factor-1 (IGF-1). This hormone is largely responsible for the healing and building of damaged muscle tissue post exercise or any other activity that causes damage to the muscle tissue. Although somewhat simplistic to say, the best way to view MGF is as a byproduct of IGF-1, specifically, IGF-1Ec, which represents the predominant splice in the two splice system created by IGF-1.

 

 

MGF Functions and Traits


IGF-1 is a hormone consisting of 70 amino acids that is structurally similar to insulin. Produced by the liver, IGF-1 production is stimulated by the production and release of Growth Hormone (GH) in the body. IGF-1 affects nearly every cell in the human body, predominantly as it pertains to cellular repair. When muscle tissue is damaged, this creates a response in the body that causes IGF-1 to be spliced into two variants, IGF-1Ec and IGF-1Ea, the former being MGF.

 

The splice to MGF activates satellite cells causing the growth of new muscle fibers in the body. Further, the presence of MGF increases the body’s rate of protein synthesis. This will cause the body to increase muscle size and more importantly repair existing damaged muscle. The recovery factor associated with MGF is without question the most important and beneficial aspect of the hormone.

 

Although the function of MGF may seem slightly confusing when you first glance, the process itself is rather simple when you look at it step-by-step:

 

IGF-1 is released due to exercise (occurs post exercise)
IGF-1 is spliced to MGF
MGF activates recovery of muscle tissue via an activation of muscle stem cells


Effects of MGF


The effects of MGF can largely be summed up by two words, hypertrophy and recovery. MGF being released into the body is beneficial for any athlete or fitness enthusiast regardless of bulking, cutting or any other phase he may be in. The release of MGF is something that occurs naturally, but in the case of performance enhancement the idea is to create a greater release of MGF than can be had naturally. The most common way to accomplish this is through the use of Human Growth Hormone (HGH). HGH carries with it many health and performance benefits, including the elevation of IGF-1 levels, in turn increasing MGF. However, direct supplementation of MGF is also possible through synthetic products.

 

Data shows that direct increases of MGF (injections) to have increased muscle fibers by 25% in a mere three weeks, where natural occurring took upwards of four months to produce 15% in rodents.

 

MGF is highly anabolic and can be a great addition to an off-season gaining phase. However, because the half-life of the product is only a few minutes and because it must be used immediately post training, it can be difficult for some people to use. For the benefits of injectable MGF to be had, it must be administered within a few minutes of a training session to catch the open window. If the individual were to train, drive home and then inject, he would have wasted the opportunity.

 

A more suitable option for many MGF users may be PEG-MGF. PEG-MGF is active in the body for several hours, whereas standard MGF only for a few minutes. Further, MGF will only remain active in the area of injection for a few moments. If you were to train biceps, for best results you would need to inject both biceps immediately post training. With PEG-MGF a single injection along with the hours of activity would allow for it to take a more full effect.

 

 

Side Effects of MGF


The side effects of MGF are somewhat lacking, meaning official data is sparse. Pain or irritation at the injected area is the most common complaint, which normally refers to a sore or itchy feeling at the injected site.

 

 

MGF Administration


MGF is an injectable peptide that is administered with an insulin needle directly into the muscle(s) trained and immediately after training. 200mcg per injection is the normal or standard dose for most and is normally used for no more than four weeks. Users who surpass four weeks of use may find the benefits quickly fall due to an adaption. For optimal results, many will supplement with MGF for four weeks and then IGF-1 for four weeks, normally IGF-1 LR3 or IGF-1 DES. Using both MGF and IGF-1 at the same time (on the same day) would prove counterproductive, as they would compete with each other. However, some individuals have reported using IGF-1 on and MGF on alternating days to avoid blunting the effects of each other. Unfortunately, data is not fully conclusive in terms of what’s officially the most effective.

 

MGF is found in freeze-dried form and mixed with a sterile solution and must remain refrigerated once reconstituted. MGF should remain stable and potent for up to six months post-mixing. It must be reiterated, for a stable MGF experience, the user will typically find PEG-MGF to be the only MGF product worth using.

 

 

Buy MGF Online


You can buy MGF online from most only research chemical companies. This is not a controlled substance and will be carried by the majority of online retailers that carry ancillaries, erectile dysfunction medications and other non-controlled peptides. Prescriptions for MGF are not required in the U.S. when purchased for research purposes. However, purchases for individual use are illegal. The laws can vary greatly from one country to the next and it’s imperative that you understand the law as it pertains to where you live before any purchase is made.

 

 

MGF Reviews


Standard MGF is very difficult to control and often hard to obtain worthwhile benefits with due to the small window of acceptable administration time. For this reason, the only MGF that makes sense to use is PEG-MGF. The addition of PEG is simply a Polyethylene glycol that increases the half-life of the MGF. It is not toxic and presents no damage to the hormone or body.

 

MGF can also be a suitable option for the anabolic steroid user who is in between steroid cycles. There is no testosterone suppression with this product. However, full results, the most gains to be made will be seen when used with anabolic steroids.

 


MGF (Mechano growth factor)
also known as IGF-1 Ec

Sequence H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
One Letter Sequence YQPPSTNKNTKSQRRKGSTFEEHK-NH2
Physical Apperance White Powder
Form & Formulations Sterile Filtered white lyophilized (freeze-dried)
Stability 2 months at room temperature 24 months from date of receipt, ­20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Purity >98% by RP-HPLC
Storage Lyophilized MGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.

 


Mechano Growth Factor (MGF) is a spliced variant of the IGF gene, which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. It is derived from IGF-1 but its sequence differs from the systemic IGF-1 produced by the liver. Natural MGF is produced locally and does not travel into the blood stream. Synthetic MGF on the other hand is water based and when administered intramuscularly it will travel into the blood stream.
MGF is expressed by mechanically overloaded muscle and plays a role in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is involved in the activation of muscle satellite cells. The cells donate nuclei to the muscle fibers that are required for repair and for the hypertrophy processes, which may have similar regulatory mechanisms. It is related very closely to insulin like growth factor, but is different in several key ways which make it a potentially even more powerful substance for the creation of lean muscle mass. When muscles are stressed to the breakdown point their recovery when boosted with Mechano Growth Factor will be greater, and more muscle size and mass is likely to be gained.

 

The primary and most effective means of reducing overall body fat percentage is to increase the lean muscle mass. Increased lean muscle will result in the usage of fat stores and calories much more effectively, creating an overall leaner body and physique.
MGF is also known as IGF-1Ec. This C-terminal peptide was found to function independently from the rest of the molecule. IGF-1 exists in multiple isoforms (tissue specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals that are a direct result of exercise overload. Immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF, which initiates hypertrophy and repair of local muscle damage. One of the principle problems that have been associated with aging is the loss of muscle mass.

 

This loss of muscle mass has been directly linked to Hormone deficiencies. As people age, they frequently are no longer producing Hormones in the required amounts. This is because their bodies lose the ability to naturally produce the Mechano Growth Factor, which helps to repair damaged muscle tissue and to build more lean muscle mass. This is linked to the decline in GH that serves as the primary instigator in the production of MGF.

 

Recent studies have also discovered two clones of the hybridonoma secreting monoclonal antibodies to the mechano-growth factor have been developed by cell fusion technique. The monoclonal antibody of one clone recognizes the human MGF peptide that is absent in insulin-like growth factor-1 (IGF-1) which comprised mostly of amino acids from 87-111. Enzyme-linked immunosorbent assay (ELISA) has further shown that there is a high affinity binding constants with the full length of the MGF and the 87-111 fragments of the clones. These can then be used for the quantitation of the MGF through sandwich type assay (Kravchenko et al. 2006).

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