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    The initial creation of the synthetic Melanotan 2 peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight.

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Melanotan II
Injecting Anabolic Steroids MT 2 Melanotan II

Injecting Anabolic Steroids MT 2 Melanotan II

The initial creation of the synthetic Melanotan 2 peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight.

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description
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Molecular formula: C50H69N15O9
Molar Mass: 1024.180
CAS number: 121062-08-6
PubChem: 92432
MeSH: melanotan-II
Melanotan 2 Structural Name: Ac-cyclo[Nle4, Asp5, D-Phe7, Lys10]α-MSH4-10-NH2

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The Development of Melanotan 2


The initial creation of the synthetic Melanotan 2 peptide can be credited to the University of Arizona. During the course of research aimed at developing a defense against skin cancer, focus was placed on developing a method of stimulating natural melanogenesis, or the natural production of melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight.

 
Initially, University of Arizona researchers attempted to directly administer the naturally occurring hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1 and Melanotan 2, which exhibit similar effects whilst possessing an extended half-life for functional therapeutic utilization.

Melanotan 2 Studies and Further Information

 

Melanotan and Melanotan 2 are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan 2 is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (a-MSH).

 

The effects of Melanotan 2 on the diet and food intake of the laboratory mice have also been investigated. It has been demonstrated that the central melanocortin (MC) has been activated by melanotan 2 when fed and induced in the mice. The six-day treatment of Melanotan 2 has shown that the peptide actually reduced the body weight and the adipose tissue in the viscera of the mice and suppressed the caloric intake of the organism. This has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese.

 

Furthermore, the same study has also demonstrated that there was a sustained increase in the available oxygen consumption in obese animals. Melanotan 2 also helped reduced the level of serum insulin and the cholesterol levels when compared with the control treatments.

 

Furthermore, it has been suggested that melanotan 2 actually lowers the level of acetylcholine A caboxylase expression and even prevented the reduction of carnitine and palmitoltransferase I mRNA in muscle-type tissues by pair-feeding in the muscles of the obese rats. Moreover, the Melanotan 2 peptide actually increased the fat catabolism in the muscles and even improved the cholesterol metabolism (Li et al. 2004).

 

 

α-Melanocyte-Stimulating Hormone Analogues (Melanotan Peptides)

 

α-Melanocyte-stimulating hormone (α-MSH) is a naturally occurring endogenous melanotan peptide hormone of the melanocortin family, which is considered to be the most important of the melanocyte-stimulating hormones when it comes to stimulating melanogenesis, a process which in mammals is responsible for hair and skin pigmentation. α-MSH also plays a role in feeding behavior, energy homeostasis, and sexual activity (Bremelanotide and Melanotan 2). α-MSH is a nonselective agonist of melanocortin receptors MC1, MC3, MC4 and MC5.

 

Melanotan 1 and Melanotan 2 activate the MC1 receptor, which is responsible for effects on skin pigmentation. Melanotan 2 and PT-141 both stimulate the MC3 and MC4 receptors which are responsible for the regulation of appetite, metabolism, and sexual behavior. However, PT-141 Bremelanotide does not stimulate the MC1 receptor.

 

A few synthetic analogues of α-MSH have been investigated for their apparent photoprotective effects against ultraviolet (UV) radiation from the sun, namely Melanotan  (afamelanotide) and Melanotan 2, referred to as Melanotan 2. Bremelanotide, another analogue of α-MSH similar to Melanotan 2, is currently under development for the treatment of sexual dysfunction. All of these melanotan peptides have significantly greater potencies than α-MSH, but with distinctive selectivity peptide profiles.

 

Buy Melanotan, Melanotan 2 and PT-141 Online Supplier

 

PeptideSciences™, the leading Melanotan 2 supplier, proudly offers a large selection of premium quality α-MSH analogues that are assayed at a minimum purity of 99%. We understand the great importance of purchasing only the highest quality melanotan peptides online to ensure maximum potency (stability) and purity of your Melanotan 1, Melanotan 2 and PT-141 when you shop online.

 

 

Sun Kissed All Year Round

 

Don't be surprised. A lot of people haven't heard of Melanotan. Melanotan is a tanning peptide that stimulates the production of melanin in the body to foster a deep, natural tan. This is the body's way of protecting itself from too much sun exposure by increasing the level of melanin in the body. Melanin is your body's natural response to UV damage. The end result is a darkening of the skin.

 

Obviously the drawback from too much tanning is the amount of damage UV radiation can do. This can lead to skin cancer and other serious health problems.

 

 

How it works?

 

Melanotan 2 works by stimulating the release of the pigment melanin from the skin. Less UV exposure is necessary with Melanotan 2 compared to “normal tanning”, and the tan that occurs with tanning injections is deeper and longer lasting than an individual’s “normal tan”. Melanotan works best (has the most noticeable effects) on people with fair skin tones.

 

 

How is MT2 Used?

 

Peptide is shipped enclosed in a vial. It is in a powder dried form that must be reconstituted using sterile water and then injected under the skin (subcutaneously) where it is is absorbed into the skin and spread throughout.

 

 

Benefits:

 

Lasting Tan: Even if dosage is stopped, a warm sun-kissed tan can last for months at a time without any exposure to the sun. Conversely, tans developed naturally fade in around a months time.

 

Flexibility of Use: Able to take a small loading dose with continued dosing until desired skin pigmentation is achieved. Once achieved only need to dose once every couple of weeks to maintain same pigment.

 

Reduced exposure to sunlight (UV rays): Melanotan still needs exposure to sunlight to be effective. However it will allow the user a significant reduction in time to develop desired tan .

 

Side effects: Side effects for Melanotan 2 include nausea, appetite loss, facial flushing and increased libido. Side effects are generally mild and tend to diminish over time. Some research suggests nausea can be reduced by injecting MT-II after dinner or before bed. Athletes and bodybuilders have injected peptides like Melanotan 2 intermittently to prolong their tan since a tan aided by Melanotan can last 2-3 times as long as a normal tan. Like other peptides, Melanotan is a fragile molecule, therefore melanotan nasal sprays, pre-mixed peptides, pills, oral and loose powder are not often legitimate for research effectiveness.

 

Dosage: Research quality peptides are supplied as a lyophilized powder that must be mixed with bacteriostatic water for injection just prior to use. A suggested research dose is weight based. Below example is for average 70kg adult

 

0.25mg-very light

 

0.5mg-light

 

1mg-common standard

 

1.5-strong

 

2mg-very strong

 

Based on this, 100kg male can take 1.5-2mg as a weekly dosage. 50kg female should start off with 0.25mg to be safe and then move to 0.5mg and 1mg if needed.

 

Pre-loading does is 2x or 3x smaller than your normal maintenance dosage. As a reminder you do not need to do this unless you are in a rush to get really dark in a matter of days.

 

Noteworthy: Many online sources sell an ineffective product. Also peptides are fragile by nature, and are not effective when they are taken orally (pills, shakes, etc) because they will be broken down by the digestive process. Instead, peptides are mixed with bacteriostatic water, and then injected under the skin with an insulin needle. Peptide injections in this manner are nearly painless, and have clinically proven effectiveness.

 

Conclusions: Melanotan not a treatment or cure for anything. Nor should it be considered a preventative treatment to skin cancer. Despite this tanning peptide being known to protect the skin through the natural tanning process, it is not in and itself a guaranteed full proof UV shield. However it is a great way for those who don't tan easily to get sun-kissed all year long with minimal exposure to the sun.



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