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Growth Hormone Release Peptide Ghrp-6 Growth Factor Receptor Epidermal made by Health-keeping Bio-technology
Growth Hormone Release Peptide Ghrp-6 Growth Factor Receptor Epidermal

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GHRP-6 is a potent stimulator of natural Growth Hormone release. GHRP-6 is a Hexa-peptide that promotes food intake by stimulating hunger and helps increase energy metabolism. Growth Hormone Releasing Peptide, similar to GHRP-6, are most commonly used for treatment of Growth Hormone (GH) deficiencies, eating disorders, obesity, etc. Research has shown that use of these HGH Peptides increases lean muscle mass, strength, stamina and decreases body fat.

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GHRP-6 is a potent stimulator of natural Growth Hormone release. GHRP-6 is a Hexa-peptide that promotes food intake by stimulating hunger and helps increase energy metabolism. Growth Hormone Releasing Peptide, similar to GHRP-6, are most commonly used for treatment of Growth Hormone (GH) deficiencies, eating disorders, obesity, etc. Research has shown that use of these HGH Peptides increases lean muscle mass, strength, stamina and decreases body fat.



Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular formula: C46H56N12O6
Molar Mass: 873.014
CAS number: 87616-84-0
PubChem: 5486806
Synonyms: Growth Hormone Releasing Peptide-6; GHRP6; GHRP 6

 

 

Growth Hormone Releasing Hexapeptide

 


 

The Development of GHRP-6

 

In 1982, the natural hormone "Growth Hormone Releasing Hormone" (GHRH) was identified after a prolonged search. Soon, researchers discovered that those GH-Releasing Peptides (specifically GHRP-6 & GHPR-2) a mode of action which bound them to and was mediated through receptors different from those for GHRH. Furthermore, researches discovered that these GH-Releasing Peptides acted synergistically with the natural hormone Growth Hormone Releasing Hormone (GHRH), which is related to Sermorelin, in both laboratory animals and humans to produce large releases of Growth Hormone.

 

In the 1980s, the first highly potent GH-Releasing peptide, GHRP-6, was developed. Due to a strong GH release response from the the peptide, it became the first member of a class called Growth Hormone secretagogues. GHRP-6 is a hexapeptide composed of 6 amino acids: L-Histidine, D-Tryptophan, L-Alanine, L-Tryptophan, D-Phenylalanine and L-Lysine.

 

The "L" form of an amino acid is the naturally occurring form and often in the nomenclature the "L" is dropped. The "D" form does not occur in nature and is the isomeric form (i.e. mirror image) of the naturally occurring "L" form. GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is composed of both natural and isomeric forms of those 6 amino acids.This sequence provides a signal to the body to begin secreting Growth Hormone release while also blocking Somatostatin, a hormone that inhibits the release of Growth Hormone. 

 

 

Studies Related to the GHRP-6 Peptide

 

Investigations reported that GHRP-6 is more efficient than GHRH itself in monkeys and performs synergistically when combined or applied together. An example of this combination would be GHRP-2 and CJC-1295. GHRP-6 is believed to be acting naturally on both pituitary and hypothalamic sites (Fairhall et al. 1995). In a time-dependent and dose-dependent manner, the primary pituitary cells of rats were demonstrated on. From the studies, the concentrations of the GHRP-6 needed for the half-maximal and maximal stimulation were 7 x 10(-9) and 10(-7) M, respectively.

 

In another study, it was concluded that the major target of the GHRP-6 in vivo (both laboratory animals and humans) is the hypothalamus. From the observation, it was concluded that the GH release induced by the central GHRP-6 injections in guinea pigs was inhibited by the central action of somatostatin.

 

Furthermore, an inhibition by somatostatin with the activated GRF neurons, induced by GHRP-6, was observed via receptors known to be located on or near the GRF themselves. This particular experiment further indicated that GHRP-6 is effectively stimulating GH release from somatotrophs through different receptors, the mechanisms of which are not yet known (Chan et al. 1989).

 

Determining how efficient and the actions of the growth hormone is dependent on the physical condition of the experimental unit. For example, in humans, GH secretion decreases with obesity. On the other hand, GHRP-6, similar to Hexarelin, showed in one case increased (almost twice that of GHRP) GH responses when administered in obese patients (Cordido et al. 1993). Though obesity has shown affecting the efficiency of the hormone, it was also suggested that GHRP-6’s effects were found to be sex- and age-independent without being affected by the noadregenic pathways using the a2 adrenergic receptors (Penalva et al. 2008).

GHRP-6 and the Growth Hormone Secretagogue Receptor

 

GHRPs are not simply surrogates of GHPR, instead GHRP-6 is an artificial activator of a separate newly discovered receptor called Growth Hormone Secretagogue Receptor (GHS-R). Soon Ghrelin was discovered, the endogenous ligand that binds to the GHS-R. Both Ghrelin and all the synthetic compounds such as GHRP-6 were termed "Growth Hormone Secretagogues" (GHSs). One side effect of GHRP-6 is a significant increase in appetite due to stimulating the release of Ghrelin, a peptide that is released naturally in the lining of the stomach that increases hunger and gastric emptying.

 

Also, GHRP-6 causes stimulation of the anterior pituitary gland which causes an increase in Growth Hormone release. The increased amounts of Growth Hormone can cause the liver to secrete the hormone IGF-1, which improves the animal body’s ability to burn fat and build muscle. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of Growth Hormone release, GHRP-6 can re-stimulate the production of Growth Hormone.

 

 

GHRP-6: An hGH Alternative?

 

What is GHRP-6?

 

GHRP-6 (Growth Hormone Releasing Peptide – 6) is a peptide hormone, basically a hexapeptide. It contains a chain made up of 6 amino acids. It is one of numerous man-made met-enkephalin analogs that incorporate unnatural D-amino acids. GHRP-6- is a non-pyrogenic and germ-free powder which is administered intramuscularly or subcutaneously. GHRP-6 is one of the true human growth hormone secretagogues (GHS).

 

A number of secretagogues (a name given to a substance which causes another substance to be secreted – in this case growth hormone) have been widely in use for their clinical activities and health promotion. GHRP-6 fuels secretion of growth hormone (GH) the same way as does the GH itself and provides similar actions on the muscle mass, joints, and skin. It has the potential to lessen or even undo several symptoms of deficiency of human growth hormone (hGH).

 

The legitimate and authorized use of hormone replacement therapy is a way of endorsing a longer and healthier life with better health outcomes. GHRP-6 is one of those which offer vigour and energy to the body. However, it is important to know that GHRP-6 is distinctive from growth hormone releasing peptide and does not have any action on the GHRH receptor, but it mainly acts at the HGH secretagogue receptor, which is known as the ghrelin receptor.Ghrelin is a powerful stimulator of the release of growth hormone from the anterior pituitary gland and is a known protector of neurons.

 

 

How Does GHRP-6 Boost HGH Levels?

 

GHRP-6 has a special role in boosting the levels of human growth hormone. This peptide acts at the hypothalamus and the pituitary in order to release Growth hormone (GH). It provides a signal to the body to initiate growth hormone (GH) secretion and its release, while on the other hand it inhibits Somatostatin, which is a hormone responsible for inhibition of Growth Hormone release.

 

GHRP-6 also enhances levels of hGH by reducing the influence of the somatostatin at the pituitary. Additionally, it has an action on somatotrophs (the pituitary cells) which encourages the discharge of GHRH (growth hormone releasing hormone) by increasing cAMP formation, which may further lead to the release of hGH from somatotroph stores.

 

An injection of GHRP-6 can raise the level of basal growth hormone to 4 times while the IGF-1 level remains boosted for seven days following its injection.


IGF-1 is the principal vehicle through which hGH affects its incredible, age-flouting attributes. High levels of IGF-1 move through the blood and enhance the metabolism rate and provide boosted energy levels for all types of physiological function. Additionally, IGF-1 works to stimulate the healthy growth of new cells within several organs and bones throughout the body. 

 

Advantages Of GHRP-6 Over HGH

 

Research studies have demonstrated that stimulation of Growth Hormone by GHRP-6 offers a number of valuable effects, for example, it can increase the muscle mass, reduce body fat, and enhance the stamina and strength, thus it can make the best use of GH formation as well as secretion.

 

Human Growth Hormone (hGH) affects absolutely every aspect of the functions of our body. During childhood, it is hGH which controls the essential growth-linked activities. When we enter into adulthood, hGH still plays an important role, yet its production decreases with an increasing age. Here comes the role of GHRP-6. GHRP-6 works to facilitate the natural production of hGH by the body. When exogenous hGH is given, it can only replace the hormones produced by our bodies and help reverse the process of aging. On the other hand, GHRP-6 stimulates the production and release of natural hGH.

 

This ultimately means that there is no competition of natural hGH with the exogenous or synthetic one. This natural hGH then helps in restoring optimal levels of growth hormone in the body and endorses youthfulness and vitality of the body, which is often lost when growth hormone levels started to decline with age. GHRP-6 not only provides the liveliness and anti-aging effects of hGH, but also it helps keep the good health of the pituitary gland. Some of the other advantages of GHRP-6 are detailed below. 

 

Benefits of GHRP-6

  • Helps to lose weight devoid of any strenuous exercises and diet
  • Make your body stamina strong and improve level of energy
  • Provides a healthier and faster metabolism
  • Improves the elasticity of the skin so it looks smoother and younger
  • Reduces of sagging and wrinkles of the skin
  • Improves memory and enhances concentration
  • Grows lustrous and heavier hair
  • Brings back the sex drive and improve performance
  • Enhances body immunity
  • Promotes deeper, longer sleep and improves the sleeping patterns. GHRH-6 dramatically enhances the formation of human growth hormone during the sleep cycle. This deep relaxing sleep and elevated production of HGH boosts the ability of the body to recover and revive from everyday life.The “pulsatile” release of growth hormone by GHRP-6 makes this peptide far better than the exogenous hGH. Also, using secretagogues like GHRP-6 is considered superior to that of synthetic hGH becausevia GHRP-6 there is a stimulation of natural GH release, without any unnecessary shutdown of the pituitary gland. Our pituitary gland is itself competent enough of secreting a great amount of GH.

 

Furthermore, GHRP-6 is an extremely effective anti-aging agent compared to hGH. It is a cost effective alternative to hGH. The expense of GHRP-6 is on average half of the expense of HGH replacement therapy because of the complex process needed to genetically engineer hGH. It appears that the potential treatment benefits provided by both GHRP-6 and hGH replacement therapy are the same but the ways via which these useful results are obtained, differ considerably.

 

 

Safety Comparison Between hGH & GHRP-6

 

GHRP-6 carries a considerably lower possibility of potential adverse effects and overdosing relative to synthetic human growth hormone. When GHRP-6 is given, our body only utilizes the amount of GHRP-6 it requires to produce a healthy quantity of hGH. GHRP-6 does not promote the body to generate too much human growth hormone. The commonly reported adverse effects are mainly the pain, itching or swelling at the injection site. GHRP-6, if used properly, is a tremendously safe and useful approach of raising natural hGH production.

 

In contrast, in addition to pain and rash at the site of injection, there are complaints of transient fever, arthralgia, resistance to insulin, prepubertal gynecomastia, benign intracranial hypertension, edema, and worsening of scoliosis with the use of exogenous human growth hormone (hGH). Given that growth hormone stimulates multiplication of cells, onset of neoplasms is also an alarming concern.

 

GHRP-6 is an incredible treatment for those suffering from the deficiencies of growth hormone.GHRP-6 injections can help restore your physical health and improve a number of significant manifestations of aging. GHRP-6, especially when coupled with a meticulous lifestyle, can help to add more happy and healthier years to your life.



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